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Formation hotspots of fluorinated pyridine intermediates

Release time: 2024-04-01 21:09:30

At present, the quinolone antibiotics that have been developed and put into mass production in China mainly include norfloxacin, ciprofloxacin, ofloxacin, enoxacin, lomefloxacin, fleroxacin, etc. Among them, norfloxacin, ciprofloxacin, and ofloxacin have the largest production volume, accounting for approximately 98% of the total production of fluoroquinolone antibiotics in China.

Quinolones are generally synthesized from fluorinated benzene rings and then condensed with piperazine (or methylpiperazine). Due to the abundant reserves of fluorite in China, it is one of the countries with the largest production of fluorinated drugs and intermediates in the world, with over 80% of fluorinated intermediates supplied for export. Overall, the development of fluorobenzene intermediates in China is relatively early, and the current production capacity is generally surplus; The development of trifluoromethylene intermediates was relatively late and has been growing rapidly in recent years; For heterocyclic aromatic compounds, especially fluorinated pyridines, only a few research units and manufacturers in China currently have the synthesis technology of fluorinated pyridine intermediates. Therefore, fluorinated pyridine intermediates will become one of the main directions for the research and development of fluorinated intermediates in China in the coming years.

Keywords: Peptide,Custom peptide,Cosmetic peptide,Semaglutide,Tirzepatide,Retatrutide etc